This podcast introduces wastewater epidemiology and explains what information related to the detection of RNA of COVID-19 virus in wastewater does and does not tell us. Wastewater epidemiology has been used for decades to track the presence of infectious diseases such as polio in communities. It has also been used to aid in the response to the opioid epidemic. Now it has gained a role in guiding state and local public health responses to COVID-19 outbreaks. This episode is the audio from a webcast moderated by Dr. Kyle Bibby (University of Notre Dame) with several speakers including Dr. Mariana Matus (Biobot), Dr. Amy Kirby (CDC), and Dr. Jennifer Murphy (CDC).